Biochemical evidence for intertypic genetic recombination of polioviruses
نویسندگان
چکیده
منابع مشابه
Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications
Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eli...
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is some evidence from studies of related species of plants that low T E a E a frequency is associated with outcrossing and high chiasma frequency is associated with selfing (reviews in GRANT 1958; BODMER and PARSONS 1962). From this it has been inferred that crossover rates have been adjusted by natural selection toward high values in selfing species to compensate for the restrictions imposed o...
متن کاملRecombination between Polioviruses and Co-Circulating Coxsackie A Viruses: Role in the Emergence of Pathogenic Vaccine-Derived Polioviruses
Ten outbreaks of poliomyelitis caused by pathogenic circulating vaccine-derived polioviruses (cVDPVs) have recently been reported in different regions of the world. Two of these outbreaks occurred in Madagascar. Most cVDPVs were recombinants of mutated poliovaccine strains and other unidentified enteroviruses of species C. We previously reported that a type 2 cVDPV isolated during an outbreak i...
متن کاملPreferred sites of recombination in poliovirus RNA: an analysis of 40 intertypic cross-over sequences.
The genome of poliovirus consists of a single strand of RNA approximately 7.5 kb long. Analysis of the sequences around 40 unique recombination sites reveals several features that differ significantly from those expected of randomly located sites. These features, which include a broad zone of elevated homology on the 3' side of the cross-over, support the theory that RNA recombination occurs by...
متن کاملMolecular basis for genetic recombination.
HE past few decades have witnessed the successive description in biochemiTcal-or “molecular”-terms of the great formal entities of classical genetics. The lickage group was early identified with the objectively seen chromosome, then the gene itself, in its wild and mutant forms, more and more closely related to the linear DNA regions thereof. We have seen the identification of the gene product ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1980
ISSN: 0014-5793
DOI: 10.1016/0014-5793(80)81229-4